A new systematic review of 172 studies including data from over 12 million adolescents across 166 countries reveals that while cross-national adolescent mental health research including low- and middle-income countries has expanded significantly, large gaps remain in global representation. The results are published in BMJ Global Health.
The review, conducted by an international research team led by the Research Center for Child Psychiatry at the University of Turku, Finland, found that inclusion of low- and middle-income countries (LMICs) in cross-national research has increased dramatically over the past 30 years, especially since 2020. However, 52 countries were not included in any of the 172 studies reviewed.
Most research relies heavily on cross-sectional, school-based surveys with self-reported questionnaires. The most commonly used international surveys were the Health Behavior in School-aged Children study (19.8%), the Global School-based Student Health Survey (12.2%), and the Program for International Student Assessment (8.1%).
The review reveals that while bullying and internalizing problems, such as anxiety and depression, are commonly studied, externalizing behaviors like aggression are often overlooked. While the prevalences of most mental health and psychosocial issues were comparable or mixed between LMICs and high-income countries, traditional bullying was reported more frequently in LMICs in the majority of reviewed studies.
Western standards pose methodological challenges for global mental health research
The lead authors, Doctoral Researcher Xiao Zhang and Postdoctoral Researcher Yuko Mori, highlight a major methodological challenge revealed by the review.
“Many of the commonly used tools were originally developed based on Western mental health constructs. This raises concerns about their validity and relevance when applied across culturally diverse settings,” they explain.
Professor Andre Sourander, Director of the Research Center for Child Psychiatry, agrees that our understanding about adolescent mental health still relies heavily on research findings from Western or high-income countries.
“Global trends, such as increased inequalities, migration, and climate change, emerging threats, such as war and pandemics, and enormously increased use of digital devices may have detrimental effects on adolescent well-being worldwide.
“Cross-cultural research on adolescent mental health including diverse societies, minorities and risk groups is highly relevant and warranted, especially since 90% of the global adolescent population resides in low and middle-income countries,” Professor Sourander emphasizes.
The researchers stress the importance of creating and validating their own culturally grounded instruments in LMICs, which could also enrich mental health research in high-income countries by offering more inclusive and globally applicable assessment frameworks.
Future studies, they argue, should employ validated tools, use multiple informant sources, and draw on representative samples that include minority populations, such as adolescents from immigrant backgrounds, those with disabilities, and Indigenous groups.
More information:
Xiao Zhang et al, Cross-national research on adolescent mental health: a systematic review comparing research in low, middle and high-income countries, BMJ Global Health (2025). DOI: 10.1136/bmjgh-2025-019267
University of Turku
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Global inequality in adolescent mental health research persists despite progress (2025, August 12)
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